Porphyrins Test Now Available
The Biomarkers of Toxicity
Porphyrins measured in urine serve as biomarkers of toxic effects on the heme biosynthetic pathway. Heme is essential for the proper function of many proteins for oxygen transport, energy production, and detoxification. Patterns of specific porphyrin elevations in urine may serve as functional markers to specific toxins, including toxic metals, such as mercury. The Porphyrins Profile measures seven porphyrins, total porphyrins, and three ratios to help differentiate heavy metal toxicity.
Elevations of the individual porphyrin species can have a number of causes, including heredity and environmental contact. Chronic exposure to toxic metals, including lead, mercury, arsenic, aluminum, and cadmium often results in organ-specific accumulation that compromises target organ physiological function. Heavy metals impair many aspects of metabolism, while chronic exposure to organic chemicals, such as pesticides, can have deleterious effects on the body's biochemistry and adversely affect cellular function.
Why Evaluate Porphyrins?
- Differentiation of heavy metal toxicity
- Biochemical damage caused by toxicant exposure
- Mercury's effect in dental patients with amalgams
- Patients before and during chelation therapy
- The toxicity of therapeutic drugs
Toxicity Components
- Multiple chemical sensitivity
- Behavioral and learning disorders
- Immune Dysfunctions
- Chronic fatigue
- Neurological and mental/emotional disorders
Other causes and conditions related to porphyria include:
Genetic Disorders
- Heredity hyperbilirubinemias
- Heredity tyrosinemia
- Bronze baby syndrome
- Erythrohepatic protoporphyria
Metabolic Disturbances
- Diabetes mellitus
- Myocardial infarction
- Hematologic diseases
- Disturbance of iron metabolism
Diseases
- Infectious diseases
- Liver disease
- Malignancies
Other Conditions
- Pregnancy
- Carbohydrate fasting
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